Templated Synthesis of Peptide Nucleic Acids via Sequence-Selective Base-Filling Reactions
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چکیده
منابع مشابه
Templated Synthesis of Peptide Nucleic Acids via Sequence-Selective Base-Filling Reactions
The templated synthesis of nucleic acids has previously been achieved through the backbone ligation of preformed nucleotide monomers or oligomers. In contrast, here we demonstrate templated nucleic acid synthesis using a base-filling approach in which individual bases are added to abasic sites of a peptide nucleic acid (PNA). Because nucleobase substrates in this approach are not self-reactive,...
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ژورنال
عنوان ژورنال: Journal of the American Chemical Society
سال: 2009
ISSN: 0002-7863,1520-5126
DOI: 10.1021/ja904712t